Made
By reducing a nitro compound
Industrially, 4-Aminophenol is made by hydrogenating nitrobenzene in acid, which rearranges to the para product (the Bamberger rearrangement), or by reducing 4-nitrophenol.
API Intermediate · Paracetamol KSM
Para-aminophenol (PAP), the key starting material for Paracetamol. Sourced worldwide by Chelora Pharmachem, Mumbai, and delivered to plants across India with a batch COA and SDS.
How Buying Works
Send the quantity, grade, delivery city and target date by email or phone. Quote CAS 123-30-8 so there is no confusion.
Price, lead time and packing in one reply, with the specification, COA and SDS/MSDS for your QA team to review.
Samples can be arranged for QC testing and vendor qualification before your commercial order.
Packed, labelled and sent with invoice, batch COA and transport documents. Repeat orders are planned with you.
Product Overview
4-Aminophenol (para-aminophenol, p-aminophenol or PAP; CAS 123-30-8) is an aromatic compound with an amino group (–NH₂) and a hydroxyl group (–OH) on opposite carbons of a benzene ring. It is a white to light-brown crystalline powder and one of the most important intermediates in the pharmaceutical industry, because it is the direct precursor of Paracetamol (acetaminophen).
India is one of the world’s major Paracetamol producers, so bulk drug plants need a steady supply of high-purity 4-Aminophenol with consistent colour, assay and impurity profile. Beyond Paracetamol, the same molecule is used in oxidative hair dyes, sulfur and azo dyes, photographic developers and fine-chemical synthesis.
As a chemical supplier in Mumbai, Chelora Pharmachem supplies 4-Aminophenol to manufacturers across India, sourcing worldwide when local supply is short, with a batch-wise COA, SDS/MSDS and specification on every order.
In Depth
4-Aminophenol, also written as 4-hydroxyaniline, belongs to the aminophenol family. Its amino group is weakly basic and its phenolic hydroxyl group is weakly acidic, so it can form salts with both strong acids and strong bases. With the two groups para to each other, the ring is electron-rich and easily oxidised.
The amino group is the more nucleophilic site, so acylating agents such as acetic anhydride react at the nitrogen first. This selectivity is what makes clean Paracetamol synthesis possible. The amino group can also be diazotised for azo dye chemistry, and the compound's reducing power is why it works as a photographic developer.
The main commercial routes start from nitrobenzene or 4-nitrophenol. Catalytic hydrogenation of nitrobenzene in dilute sulfuric acid passes through phenylhydroxylamine, which rearranges to 4-Aminophenol, with aniline as the main by-product. Reducing 4-nitrophenol with hydrogen or iron is the other established route.
Paracetamol is made by acetylating 4-Aminophenol, then crystallising and purifying the crude product. Pharmacopoeias limit residual 4-Aminophenol in the finished API, so the reaction and purification have to be well controlled, and the quality of the incoming material affects colour, yield and the purification load.
Compare assay, appearance and colour, melting range, loss on drying, ash and related substances against your specification. Dark or strongly coloured material can point to oxidation, so check packing integrity, batch date and storage conditions on receipt. Ask for the COA and SDS of the actual batch, and test a sample during vendor qualification.
Chelora Pharmachem supplies 4-Aminophenol (CAS 123-30-8) from its centralized sales office in Mumbai to API, dye and specialty-chemical manufacturers across India. Share the grade, quantity, packing and delivery location, and our team will reply with price, lead time and documents, from trial lots to regular bulk supply.
Global Sourcing
Our focus is the Indian market. When local supply is short, or you need a specific origin or grade, our international sourcing desk brings 4-Aminophenol in from trusted producers abroad, and our Mumbai team handles import, documents and delivery to your plant.
Product Profile
The identifiers and properties purchase and QA teams ask for first. Batch values are always confirmed on the COA.
Identity
EC 204-616-2. Also sold as p-aminophenol, PAP or 4-hydroxyaniline.
109.13 g/mol. A benzene ring with –OH and –NH₂ on opposite carbons.
Appearance
White to light brown. It darkens in air and light, so it ships sealed.
Solubility
In water at 25 °C. Soluble in acetone, ethyl acetate and acetonitrile.
Technical Data
Reference data for 4-Aminophenol, useful when writing a specification, checking an SDS or planning storage and transport.
| Property | Value |
|---|---|
| IUPAC name | 4-Aminophenol |
| Synonyms | p-Aminophenol, para-aminophenol, PAP, 4-hydroxyaniline, 4-amino-1-hydroxybenzene |
| CAS number | 123-30-8 |
| EC number | 204-616-2 |
| PubChem CID | 403 |
| Molecular formula | C6H7NO |
| Molar mass | 109.13 g/mol |
| Appearance | White to light-brown crystalline powder; darkens on exposure to air and light |
| Melting point | About 187 °C (commercial specifications typically 186–190 °C) |
| Boiling point | About 284 °C |
| Density | About 1.13 g/cm³ |
| Solubility in water | About 1.5 g per 100 mL at 25 °C |
| Other solvents | Soluble in acetone, ethyl acetate and acetonitrile; slightly soluble in toluene and diethyl ether |
| Acidity (pKa) | 5.48 (amino group) and 10.30 (phenol group) |
| HS code | 2922.29 |
| UN number | UN 2512, Aminophenols (o-, m-, p-), class 6.1, packing group III |
Literature values for reference. Supplied material is tested batch-wise and reported on the COA.
Applications
Its best-known job is Paracetamol. The same molecule also feeds hair-colour, dye and photo-chemical makers, and R&D labs.
4-Aminophenol is the final intermediate in the industrial Paracetamol route: acetylating it with acetic anhydride gives the API. By molar mass, about 0.72 kg goes into every kilogram of Paracetamol, before process losses.
Key starting material (KSM)
Trial and pilot quantities for route development, validation and vendor qualification, from samples up to regular bulk supply.
Trial to bulk quantities
A primary intermediate in oxidative (permanent) hair dyes, where it builds red-brown shades together with couplers. Cosmetic use is regulated, so formulators work to the limits that apply in their market.
Regulated cosmetic use
An intermediate for sulfur and azo dyes and for other aromatic fine chemicals made by dye and specialty-chemical producers.
Dye intermediate
The developing agent in classic black-and-white film developers such as Rodinal, still used in specialist photo chemistry.
Photo chemicals
Quality & Compliance
Every supply is backed by the documents your QA, regulatory and stores teams expect.
COA, batch-wise
Tests, limits and results for the exact batch you receive, shared before dispatch.
SDS / MSDS
Hazards, safe handling, storage, transport and first-aid measures for 4-Aminophenol.
Technical data
Typical properties and the specification we supply against, to match with your in-house spec.
On request
Additional documents for vendor approval and audits can be arranged on request.
Safety & Handling
A short summary for stores, production and EHS teams. It does not replace the Safety Data Sheet supplied with every batch.
Harmful if swallowed or inhaled, suspected of causing genetic defects, and very toxic to aquatic life with long-lasting effects. Signal word: Warning. Some suppliers’ SDS also list skin sensitisation.
H302H332H341H400H410
Chemical-resistant gloves, safety goggles and a dust mask or respirator where dust can form. Use local exhaust ventilation, and do not eat, drink or smoke while handling.
Keep containers tightly closed in a cool, dry, well-ventilated store, protected from light and air and away from strong oxidising agents.
Shipped as a dangerous good: UN 2512, Aminophenols (o-, m-, p-), class 6.1 (toxic), packing group III, packed and labelled to match.
Avoid raising dust, sweep spilled material into closed containers for disposal, and keep it out of drains, soil and water courses.
PAN India Delivery
From our centralized sales office in Mumbai, we supply 4-Aminophenol to buyers in every major manufacturing cluster.
MumbaiMumbai, Thane, Navi Mumbai, Tarapur, Boisar, Pune and Aurangabad.
AhmedabadAhmedabad, Vadodara, Ankleshwar and Vapi.
HyderabadHyderabad and Visakhapatnam.
BaddiBaddi and Haridwar.
GoaPharma and chemical units across Goa.
BengaluruBengaluru and Chennai.
IndoreIndore, Pithampur and Sikkim.
Specification
A typical commercial specification for synthesis-grade 4-Aminophenol. Share your in-house specification and we quote against it.
The Chemistry
Made
Industrially, 4-Aminophenol is made by hydrogenating nitrobenzene in acid, which rearranges to the para product (the Bamberger rearrangement), or by reducing 4-nitrophenol.
Used
Acetic anhydride puts an acetyl group on the nitrogen, giving N-(4-hydroxyphenyl)acetamide: Paracetamol. Unreacted 4-Aminophenol is a controlled impurity in the finished API, so purity going in matters.
Tested
Each batch is reported on a COA covering appearance, identification, assay, melting range, loss on drying, ash and related substances, so your QC team can release it quickly.
Stored
It oxidises slowly in air and light and turns pink to brown. Keep drums closed, cool and dry, and follow the SDS for handling and protective equipment.
Glossary
Terms you will meet on quotations, specifications and documents for 4-Aminophenol.
FAQ
Anything else, call +91 98191 11179 or write to source@chelorapharmachem.com.
Request a Quote4-Aminophenol (CAS 123-30-8) is the key starting material for Paracetamol (Acetaminophen), one of the most widely produced APIs. It is also used to make hair dyes, other dyes and photographic developers.
The CAS number is 123-30-8. Its formula is C6H7NO and its molar mass is 109.13 g/mol. Quoting the CAS number on your enquiry avoids confusion with its isomers, 2-Aminophenol and 3-Aminophenol.
Yes. 4-Aminophenol, p-aminophenol, para-aminophenol, PAP and 4-hydroxyaniline are names for the same substance, CAS 123-30-8.
They are isomers with the same formula. In 4-Aminophenol the amino and hydroxyl groups sit on opposite carbons of the ring (para), while in 2-Aminophenol they are next to each other (ortho). They have different CAS numbers and uses, and only 4-Aminophenol is the Paracetamol starting material.
In theory about 0.72 kg, from the molar masses: 109.13 g/mol for 4-Aminophenol and 151.16 g/mol for Paracetamol. Real consumption is a little higher, depending on your process yield.
It oxidises slowly when exposed to air and light, forming coloured products. That is why it is packed in closed, lined containers and should be stored cool, dry and away from light. Strongly discoloured material should be checked against the specification before use.
Keep it in tightly closed containers in a cool, dry and well-ventilated store, protected from light and air and away from strong oxidising agents. Follow the storage section of the SDS supplied with the batch.
4-Aminophenol is generally classified under HS subheading 2922.29, which covers amino-phenols. Confirm the full national tariff code with your customs broker before import or export.
Yes. It is harmful if swallowed or inhaled, suspected of causing genetic defects and very toxic to aquatic life, and it travels as a dangerous good (UN 2512, class 6.1). Read the SDS before handling, and use gloves, eye protection and dust control.
We provide a batch-wise Certificate of Analysis (COA), SDS/MSDS and specifications. Additional documents for vendor qualification can be arranged on request.
Yes. We handle requirements from samples and trial lots for R&D and vendor approval up to regular bulk supply for commercial production, subject to product availability.
We supply buyers across India, including Maharashtra, Gujarat, Telangana, Andhra Pradesh, Himachal Pradesh, Goa, Karnataka, Tamil Nadu, Madhya Pradesh, Uttarakhand and Sikkim, from our centralized sales office in Mumbai.
Email source@chelorapharmachem.com or source@cheloragroup.com, call +91 98191 11179, or use the enquiry form on this page. Include the quantity, grade, delivery location and target date.
Request a Quote
Tell us the quantity, grade and delivery location. Our centralized sales team replies with competitive pricing, lead time and documentation.
