API & Agro Intermediate · Oxime Reagent
Hydroxylamine sulfate (hydroxylammonium sulphate, HAS), the stable solid source of hydroxylamine for oximes, hydroxamic acids and isoxazoles in API and agrochemical synthesis. Supplied by Chelora Pharmachem, Mumbai, and delivered across India with a batch COA and SDS.
How Buying Works
Send the quantity, grade (technical, LR or AR), delivery city and target date. Quote CAS 10039-54-0 so there is no confusion.
Price, lead time and packing in one reply, with the specification, COA and SDS/MSDS for your QA team to review.
Samples can be arranged for QC testing, process trials and vendor qualification before your commercial order.
Packed, labelled and sent with invoice, batch COA and transport documents. Repeat orders are planned with you.
Product Overview
Hydroxylamine sulfate (hydroxylammonium sulphate, HAS, bis(hydroxylammonium) sulphate; CAS 10039-54-0) is the sulphate salt of hydroxylamine, (NH3OH)2SO4. It is a white, slightly hygroscopic, odourless crystalline powder that dissolves freely in water to give an acidic solution. Free hydroxylamine is unstable, so this salt is the practical way to store, ship and dose it: each kilogram carries about 0.40 kg of hydroxylamine, released in the reactor when a base is added, which is why chemists often call it a hydroxylamine source rather than a reagent in its own right.
Its main job is turning aldehydes and ketones into oximes, esters into hydroxamic acids and nitriles into amidoximes, so it appears early in many API and agrochemical routes, including isoxazole rings and oxime-carbamate insecticides. On a much larger scale, cyclohexanone oxime made with hydroxylamine sulphate is the step before caprolactam and nylon 6. It is also a reducing agent and antioxidant in colour photographic developers, rubber and polymer production, metal surface treatment and analytical chemistry.
As a chemical supplier in Mumbai, Chelora Pharmachem supplies technical, laboratory and analytical-grade hydroxylamine sulfate to API, agrochemical, dye and specialty-chemical manufacturers across India, with a batch-wise COA, SDS/MSDS and specification, from trial lots to regular bulk supply. Because it is a Class 8 dangerous good, every dispatch moves with proper labelling and transport documents. For the chlorination and acylation steps that often run in the same plants, we also supply Thionyl Chloride.
In Depth
Hydroxylamine sulfate is an ionic salt: two hydroxylammonium cations, NH₃OH⁺, balance one sulphate anion. The salt is far more stable than free hydroxylamine, which is why industry handles hydroxylamine in this form. It dissolves freely in water and gives a mildly acidic solution, because the hydroxylammonium ion is a weak acid. It is also a strong reducing agent, which explains its uses in developers, rubber and analysis.
In the reactor, a base such as sodium hydroxide, sodium acetate, sodium carbonate or ammonia releases free hydroxylamine, which attacks carbonyl groups. Aldehydes and ketones give oximes, esters give hydroxamic acids, nitriles give amidoximes and isocyanates give N-hydroxyureas. Oximes can then be reduced to amines, rearranged to amides or cyclised into isoxazoles. Heat and strong alkali together must be controlled, as free hydroxylamine can decompose violently.
Industrial routes include the Raschig process, in which nitrite is reduced with bisulphite and sulphur dioxide at low temperature and the hydroxylamine disulphonate formed is hydrolysed; catalytic hydrogenation of nitric oxide over platinum in sulphuric acid; and hydrolysis of methyl ethyl ketone oxime with sulphuric acid. The solution is then crystallised, separated from ammonium sulphate and dried to the purity required.
Oxime formation is often an early step in a synthesis. The oxime may be the target itself, be reduced to a primary amine, or be cyclised with a 1,3-dicarbonyl compound into an isoxazole ring, found in several sulfa drugs. Hydroxamic acids, used as metal-binding groups in enzyme-inhibitor APIs, are made from esters and hydroxylamine. Choosing the sulphate rather than the hydrochloride keeps chloride out of the process.
Confirm the grade first, then compare assay, ammonium sulphate content, pH, chloride, iron and heavy metals, and moisture, since the salt is slightly hygroscopic. Iron and other metals can catalyse hydroxylamine decomposition, so low metal content matters for both quality and safety. Check the packing too: lined bags or drums, never bare metal containers. Ask for the COA and SDS of the actual batch.
Chelora Pharmachem supplies hydroxylamine sulfate (CAS 10039-54-0) from its centralized sales office in Mumbai to API, agrochemical, dye and specialty-chemical manufacturers across India. As a Class 8 dangerous good, it moves with proper labelling and transport documents. Share the grade, quantity, packing and delivery location, and our team replies with price, lead time and documents, from trial lots to regular bulk supply.
Global Sourcing
Our focus is the Indian market. When local supply is short, or you need a specific origin or grade, our international sourcing desk brings hydroxylamine sulfate in from trusted producers abroad, and our Mumbai team handles import, dangerous-goods documents and delivery to your plant.
Product Profile
The identifiers and properties purchase and QA teams ask for first. Batch values are always confirmed on the COA.
Identity
EC 233-118-8. Also sold as hydroxylammonium sulphate, hydroxylamine sulphate or HAS.
Two hydroxylammonium ions, NH₃OH⁺, paired with one sulphate ion.
Appearance
White crystalline powder, slightly hygroscopic. Decomposes on heating instead of melting cleanly.
Solubility
In water at 20 °C, giving an acidic solution (pH about 3.6 at 10 g/L). Only slightly soluble in alcohol.
Technical Data
Reference data for Hydroxylamine Sulfate, useful when writing a specification, checking an SDS or planning storage and transport.
| Property | Value |
|---|---|
| IUPAC name | Bis(hydroxylammonium) sulfate |
| Synonyms | Hydroxylammonium sulphate, hydroxylamine sulphate, hydroxylamine neutral sulphate, HAS |
| CAS number | 10039-54-0 |
| EC number | 233-118-8 |
| PubChem CID | 24846 |
| Molecular formula | (NH3OH)2SO4 (H8N2O6S) |
| Molar mass | 164.14 g/mol |
| Hydroxylamine content | About 40.2% NH2OH by weight (theoretical) |
| Appearance | White or colourless crystalline powder; slightly hygroscopic |
| Melting point | Decomposes on heating; literature values range from about 120 °C to 170 °C (dec.) |
| Density | About 1.88 g/cm³ at 20 °C |
| Bulk density | About 1,100 kg/m³ |
| Solubility in water | About 58.7 g per 100 mL (587 g/L) at 20 °C |
| Other solvents | Slightly soluble in alcohol |
| pH | About 3.6 (10 g/L in water, 20 °C) |
| Stability | Stable when cool and dry; releases free hydroxylamine with alkalis, which can decompose violently when heated |
| HS code | 2825.10 (India: 2825 10 40) |
| Transport | UN 2865, Hydroxylamine sulphate, Class 8, packing group III; confirm with the batch SDS |
Literature values for reference. Supplied material is tested batch-wise and reported on the COA.
Applications
Its main job is supplying hydroxylamine for oximes and hydroxamic acids. The same salt is a reducing agent in photography, rubber, metal treatment and the laboratory.
Used to convert aldehydes and ketones into oximes, esters into hydroxamic acids and nitriles into amidoximes. These steps lead to amines, isoxazole rings and metal-binding hydroxamate groups found in a range of APIs, from sulfa drugs to enzyme inhibitors, in both development and commercial batches.
Pharma intermediate
A starting material for oxime-based insecticides such as the oxime carbamates, and for isoxazole and other heterocyclic herbicides and fungicides. Agrochemical technical makers use it at the oxime-forming stage, where consistent assay and low iron help keep yields and impurity profiles steady.
Agro intermediate
Cyclohexanone reacts with hydroxylamine sulphate to give cyclohexanone oxime, which a Beckmann rearrangement turns into caprolactam, the monomer of nylon 6 fibres and plastics. Large caprolactam plants usually make hydroxylamine in-house; merchant material serves smaller producers of ketoximes and aldoximes.
Nylon 6 value chain
In colour photographic developers it acts as a preservative and antioxidant. In rubber and polymer production it is a short-stop that ends radical emulsion polymerisation, a viscosity stabiliser for natural rubber and an antioxidant, and it is used in some anti-skinning and textile dye-fixing applications.
Reducing agent & stabiliser
A reducing agent in steel surface treatment and in the plating of metals and plastics. In the laboratory it reduces iron(III) to iron(II) before colorimetric iron tests, and hydroxylamine salts are used to determine aldehydes and ketones through oxime formation.
Surface & lab use
Quality & Compliance
Every supply is backed by the documents your QA, regulatory and stores teams expect.
COA, batch-wise
Tests, limits and results for the exact batch you receive, shared before dispatch.
SDS / MSDS
Hazards, safe handling, storage, transport and first-aid measures for Hydroxylamine Sulfate.
Technical data
Typical properties and the specification we supply against, to match with your in-house spec.
On request
Additional documents for vendor approval and audits can be arranged on request.
Safety & Handling
A short summary for stores, production and EHS teams. It does not replace the Safety Data Sheet supplied with every batch.
May be corrosive to metals, harmful if swallowed or in contact with skin, causes skin and serious eye irritation, may cause an allergic skin reaction, is suspected of causing cancer, may damage the blood through repeated exposure, and is very toxic to aquatic life. Signal word: Warning. Check the SDS of the batch for the classification that applies.
H290H302H312H315H317H319H351H373H400
Wear chemical safety goggles, suitable gloves, protective clothing and a dust mask or respirator where dust can form, as it is absorbed through the skin and can cause methaemoglobinaemia. Use local exhaust ventilation, and do not eat, drink or smoke while handling.
Keep in the original lined, tightly closed containers in a cool (about 15–25 °C), dry, well-ventilated and locked store. Do not use metal containers, and keep away from heat, alkalis, oxidising agents, nitrites, nitrates and powdered metals.
Regulated as a dangerous good: UN 2865, Hydroxylamine sulphate, Class 8 (corrosive), packing group III, for road, sea and air. It may also be marked as a marine pollutant. Confirm with the transport section of the batch SDS.
Avoid raising dust, sweep spilled material into closed, non-metal containers for disposal, and keep it out of drains, soil and water courses, as it is very toxic to aquatic life.
PAN India Delivery
From our centralized sales office in Mumbai, we supply Hydroxylamine Sulfate to buyers in every major manufacturing cluster.
MumbaiMumbai, Thane, Navi Mumbai, Tarapur, Boisar, Pune and Aurangabad.
AhmedabadAhmedabad, Vadodara, Ankleshwar and Vapi.
HyderabadHyderabad and Visakhapatnam.
BaddiBaddi and Haridwar.
GoaPharma and chemical units across Goa.
BengaluruBengaluru and Chennai.
IndoreIndore, Pithampur and Sikkim.
Specification
A typical specification for high-purity (AR-type) hydroxylamine sulfate. Technical grades have wider limits; share your in-house specification and we quote against it.
The Chemistry
Made
Nitrite is reduced with bisulphite and sulphur dioxide, or nitric oxide is hydrogenated over a platinum catalyst in sulphuric acid. Either way the hydroxylamine ends up as its sulphate salt, which is crystallised, separated from ammonium sulphate and dried.
Used
A base releases hydroxylamine in situ, which condenses with a ketone or aldehyde to give an oxime and water, or reacts with an ester to give a hydroxamic acid. Careful dosing, temperature and pH control keep the reaction clean and safe.
Tested
Each batch is reported on a COA covering appearance, identification, assay, pH, ammonium sulphate, chloride, iron, heavy metals and sulphated ash, so your QC team can compare it with your specification and release it quickly for production.
Stored
It is slightly hygroscopic and decomposes on heating. Keep lined bags and drums closed, cool and dry, away from bases, oxidisers, nitrites and metals, never in bare metal containers, and follow the SDS for handling and protective equipment.
Glossary
Terms you will meet on quotations, specifications and documents for Hydroxylamine Sulfate.
FAQ
Anything else, call +91 98191 11179 or write to source@chelorapharmachem.com.
Request a QuoteHydroxylamine sulfate (CAS 10039-54-0) is used to make oximes, hydroxamic acids, amidoximes and isoxazoles in API and agrochemical synthesis, and cyclohexanone oxime for caprolactam and nylon 6. It is also a reducing agent and stabiliser in colour photographic developers, rubber and polymer production, metal surface treatment and laboratory analysis.
The CAS number is 10039-54-0 and the EC number is 233-118-8. Its formula is (NH3OH)2SO4 (H8N2O6S) and its molar mass is 164.14 g/mol. Quoting the CAS number avoids confusion with hydroxylammonium hydrogen sulphate (CAS 10046-00-1) and hydroxylamine hydrochloride (CAS 5470-11-1).
Yes. Hydroxylamine sulfate, hydroxylammonium sulphate, bis(hydroxylammonium) sulphate and HAS are names for the same substance, CAS 10039-54-0. It is sometimes called hydroxylamine neutral sulphate to tell it apart from the acid (hydrogen) sulphate.
Both are stable salts that release hydroxylamine when a base is added. Hydroxylamine hydrochloride (NH2OH·HCl, CAS 5470-11-1) brings chloride into the process, while the sulphate brings sulphate and is the form used at industrial scale, as in caprolactam production. Many oxime steps can use either, but check your validated route before switching.
About 40.2% by weight. One mole of the salt (164.14 g) carries two moles of hydroxylamine (2 × 33.03 g), so roughly 2.5 kg of hydroxylamine sulfate supplies 1 kg of hydroxylamine, before allowing for assay and process losses.
We supply technical grade for industrial and synthesis use, and laboratory (LR) and analytical reagent (AR) grades, subject to availability. Tell us the grade, the assay and impurity limits you need, and the pack size when you enquire.
Keep it in tightly closed, lined, non-metal containers in a cool, dry, well-ventilated store, away from heat, alkalis, oxidising agents, nitrites and metals. It is slightly hygroscopic. Follow the storage section of the SDS supplied with the batch.
Hydroxylamine sulfate is generally classified under HS subheading 2825.10, which covers hydrazine, hydroxylamine and their inorganic salts; India uses 2825 10 40 for hydroxylamine sulphate. Confirm the full national tariff code with your customs broker before import or export.
Yes. It is harmful if swallowed or in contact with skin, irritates skin and eyes, may cause skin allergy, is suspected of causing cancer, may damage the blood on repeated exposure, is corrosive to metals and is very toxic to aquatic life. It can decompose violently if heated, especially with alkalis. Read the SDS before handling.
Yes. It is regulated as UN 2865, Hydroxylamine sulphate, Class 8 (corrosive), packing group III, for road, sea and air, and may be marked as a marine pollutant for sea transport. Always check the transport section of the SDS supplied with the batch.
We provide a batch-wise Certificate of Analysis (COA), SDS/MSDS and specifications. Additional documents for vendor qualification can be arranged on request.
Yes. We handle requirements from samples and trial lots for R&D, process development and vendor approval up to regular bulk supply for commercial production, subject to product availability.
We supply buyers across India, including Maharashtra, Gujarat, Telangana, Andhra Pradesh, Himachal Pradesh, Goa, Karnataka, Tamil Nadu, Madhya Pradesh, Uttarakhand and Sikkim, from our centralized sales office in Mumbai.
Email source@chelorapharmachem.com or source@cheloragroup.com, call +91 98191 11179, or use the enquiry form on this page. Include the quantity, grade, delivery location and target date.
Request a Quote
Tell us the quantity, grade and delivery location. Our centralized sales team replies with competitive pricing, lead time and documentation.
