Vitamin B5 · Pharma, Food, Feed & Cosmetic Grades
Calcium Pantothenate (calcium D-pantothenate, CAS 137-08-6) is the stable salt form of vitamin B5, used in multivitamins, fortified foods, feed premixes and hair care. Supplied by Chelora Pharmachem, Mumbai, and delivered across India with a batch COA and SDS.
How Buying Works
Send the quantity, grade (IP, BP, USP, EP, FCC or 98% feed), delivery city and target date. Quote CAS 137-08-6 so there is no confusion.
Price, lead time and packing in one reply, with the specification, COA and SDS/MSDS for your QA team to review.
Samples can be arranged for QC testing, blending and stability trials, and vendor qualification before your commercial order.
Packed, labelled and sent with invoice, batch COA and transport documents. Repeat orders are planned with you.
Product Overview
Calcium Pantothenate (calcium D-pantothenate, vitamin B5 calcium salt; CAS 137-08-6) is the calcium salt of D-pantothenic acid, vitamin B5. It is a white, slightly hygroscopic powder, freely soluble in water and slightly soluble in ethanol, that decomposes at about 195 °C. Free pantothenic acid is an unstable, viscous oil, so this crystalline salt is the usual way vitamin B5 is weighed, blended and sold. In the body it is built into coenzyme A, which is central to the metabolism of fats, carbohydrates and proteins.
Calcium pantothenate is the standard vitamin B5 source in B-complex and multivitamin tablets, capsules and syrups, and in fortified cereals, infant and clinical nutrition and health drinks. Feed manufacturers use 98% feed grade in vitamin premixes for pigs and poultry, and it also appears in shampoos, hair tonics and cell-culture media. Only the D-form is biologically active: racemic DL-calcium pantothenate (CAS 6381-63-1) has about half the activity, and panthenol, the related alcohol used widely in cosmetics, is a different substance.
As a chemical supplier in Mumbai, Chelora Pharmachem supplies calcium pantothenate in IP, BP, USP and EP pharmacopoeia grades, FCC food grade and 98% feed grade to formulation, nutraceutical, food, premix and personal-care manufacturers across India, with a batch-wise COA, SDS/MSDS and specification, from sample lots to regular bulk supply. Our team can help you match the grade and physical form, powder or granular, to your process. We also supply Niacinamide (Vitamin B3), another B vitamin used alongside it in tablets and premixes.
In Depth
Each pantothenate anion is a D-pantoic acid unit joined through an amide bond to β-alanine, ending in a carboxylate. Two anions balance one calcium ion, giving C₁₈H₃₂CaN₂O₁₀. The single stereocentre has the (R) configuration, which makes the salt dextrorotatory, with a specific rotation of about +25.5° to +27.5°. It contains about 8.2–8.6% calcium and 5.7–6.0% nitrogen.
Calcium pantothenate dissolves to release pantothenate, which cells use to make coenzyme A and acyl carrier protein. These carry acetyl and fatty-acyl groups through energy metabolism and the synthesis of fats, cholesterol and acetylcholine. Only the D-isomer is used by the body, which is why the optical rotation is tested and why racemic material is labelled by its D-pantothenate equivalent.
Industrial synthesis starts with an aldol reaction of isobutyraldehyde and formaldehyde. The aldehyde is converted to its cyanohydrin and cyclised to racemic pantolactone, which is resolved, chemically or enzymatically, to D-pantolactone; the L-form is racemised and recycled. D-Pantolactone is then condensed with calcium β-alaninate, and the calcium pantothenate is isolated and dried as powder or granules.
Calcium pantothenate is the usual vitamin B5 source in tablets, capsules and premixes because it is a stable, non-volatile solid that blends evenly with other vitamins and minerals. It is hygroscopic and sensitive to strong acid, alkali and prolonged heat, so tablet makers choose granular or directly compressible forms and keep moisture low in the blend and the pack.
Confirm the form first, D- (CAS 137-08-6) or racemic DL- (CAS 6381-63-1), then the grade. Compare assay, specific optical rotation, pH, loss on drying, calcium and nitrogen content, chlorides, 3-aminopropionic acid and elemental impurities. Feed buyers usually check assay and flow, and tablet makers particle size. Ask for the COA and SDS of the actual batch.
Chelora Pharmachem supplies calcium pantothenate (CAS 137-08-6) from its centralized sales office in Mumbai to formulation, nutraceutical, food, premix and feed manufacturers across India. Share the grade, quantity, packing and delivery location, and our team replies with price, lead time and documents, from sample and trial lots to regular bulk supply, with imports arranged when local stock is short.
Global Sourcing
Our focus is the Indian market. When local supply is short, or you need a specific origin, grade or granular form, our international sourcing desk brings calcium pantothenate in from trusted producers abroad, and our Mumbai team handles import, documents and delivery to your plant.
Product Profile
The identifiers and properties purchase and QA teams ask for first. Batch values are always confirmed on the COA.
Identity
EC 205-278-9. The D-form; racemic DL-calcium pantothenate is CAS 6381-63-1.
One D-pantothenate anion shown; two of them balance each Ca²⁺ ion.
Appearance
White or almost white, slightly hygroscopic powder or granules. Almost odourless.
Solubility
Freely soluble in water at 20 °C; slightly soluble in ethanol, soluble in glycerol.
Technical Data
Reference data for Calcium Pantothenate, useful when writing a specification, checking an SDS or planning storage and transport.
| Property | Value |
|---|---|
| IUPAC name | Calcium bis{3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanoate} |
| Synonyms | Calcium D-pantothenate, D-calcium pantothenate, vitamin B5 calcium salt, D-pantothenic acid hemicalcium salt |
| CAS number | 137-08-6 (D-form); 6381-63-1 for racemic DL-calcium pantothenate |
| EC number | 205-278-9 |
| PubChem CID | 443753 |
| Molecular formula | C18H32CaN2O10 |
| Molar mass | 476.53 g/mol |
| Appearance | White or almost white, slightly hygroscopic powder or granules |
| Melting point | Decomposes at about 190–200 °C (literature 195–196 °C, with decomposition) |
| Specific optical rotation | +25.5° to +27.5° (Ph. Eur., 5% in water, dried basis) |
| Density | About 1.2 g/cm³ (SDS values 1.16–1.27 g/cm³) |
| Solubility in water | Freely soluble: about 350 g/L at 20 °C |
| Other solvents | Slightly soluble in ethanol and acetone; soluble in glycerol |
| pH | 6.8–8.0 (5% solution in water) |
| Calcium content | 8.2–8.6% (dried basis) |
| HS code | 2936.24 (Indian tariff item 2936 24 00) |
| Transport | Not regulated as a dangerous good for road, sea or air; confirm with the batch SDS |
Literature values for reference. Supplied material is tested batch-wise and reported on the COA.
Applications
Its main job is vitamin B5 in medicines, supplements, fortified foods and animal feed, with hair care and cell-culture media as smaller, specialised uses.
Calcium pantothenate is the standard vitamin B5 source in B-complex and multivitamin tablets, capsules, syrups and effervescent products, and in medicines for vitamin B deficiency. It is stable, easy to blend and available in granular forms for direct compression.
Pharma & nutraceutical
FCC food-grade calcium pantothenate is added through vitamin premixes to breakfast cereals, infant formula, clinical and sports nutrition, health drinks and fortified flour, to restore or add vitamin B5. It suits dry blends that are not exposed to high heat for long.
Food & beverage
Feed-grade calcium pantothenate, usually 98%, supplies vitamin B5 in premixes for pigs, poultry, cattle and aquaculture. Deficiency in pigs causes poor growth and a typical goose-stepping gait, so it is a routine premix vitamin. Premix makers look for free-flowing, evenly dispersing material.
Feed additive
Shampoos, conditioners, hair tonics and some creams use calcium pantothenate as a conditioning ingredient. Panthenol (provitamin B5), the related alcohol, is more common in cosmetics, so confirm which ingredient your formula specifies before ordering, as the two are not interchangeable.
Personal care
Calcium D-pantothenate is a standard vitamin in cell-culture media and in microbiological growth media used for fermentation and testing, because many cells and organisms cannot make it. These uses call for high-purity material with tight assay and low impurities.
Biotech & lab
Quality & Compliance
Every supply is backed by the documents your QA, regulatory and stores teams expect.
COA, batch-wise
Tests, limits and results for the exact batch you receive, shared before dispatch.
SDS / MSDS
Hazards, safe handling, storage, transport and first-aid measures for Calcium Pantothenate.
Technical data
Typical properties and the specification we supply against, to match with your in-house spec.
On request
Additional documents for vendor approval and audits can be arranged on request.
Safety & Handling
A short summary for stores, production and EHS teams. It does not replace the Safety Data Sheet supplied with every batch.
No EU harmonised classification. Major producers’ SDS, including the REACH-registered material, list it as not classified as hazardous, while a few supplier SDS add skin, eye or respiratory irritation (H315, H319, H335). Check the SDS of the batch for the classification that applies.
Wear safety glasses, gloves and a dust mask where dust can form. Use local exhaust ventilation at charging and weighing points, wash hands after handling, and do not eat, drink or smoke in the work area.
Keep containers tightly closed in a cool, dry, well-ventilated store, protected from moisture and heat and away from strong oxidising agents, strong acids and strong bases.
Fine powder can form explosive dust clouds in air, so avoid dust build-up, earth equipment and keep ignition sources away. Calcium pantothenate is not regulated as a dangerous good for road, sea or air transport and has no UN number.
Readily biodegradable and of low aquatic toxicity, but sweep or vacuum spills into closed containers without raising dust and keep the material out of drains and water courses.
PAN India Delivery
From our centralized sales office in Mumbai, we supply Calcium Pantothenate to buyers in every major manufacturing cluster.
MumbaiMumbai, Thane, Navi Mumbai, Tarapur, Boisar, Pune and Aurangabad.
AhmedabadAhmedabad, Vadodara, Ankleshwar and Vapi.
HyderabadHyderabad and Visakhapatnam.
BaddiBaddi and Haridwar.
GoaPharma and chemical units across Goa.
BengaluruBengaluru and Chennai.
IndoreIndore, Pithampur and Sikkim.
Specification
A typical specification for pharmacopoeia-grade calcium pantothenate (IP / BP / EP; USP limits differ slightly). Share your in-house, FCC or feed specification and we quote against it.
The Chemistry
Made
Isobutyraldehyde and formaldehyde are built up into racemic pantolactone, which is resolved to the D-form. D-Pantolactone is then ring-opened by calcium β-alaninate to give calcium D-pantothenate, which is isolated and dried as a fine powder or granules.
Used
Calcium pantothenate is blended into vitamin tablets and capsules, food and infant-nutrition premixes and feed premixes, and dissolved into shampoos and culture media. Its high water solubility helps it disperse, but moisture and prolonged heat should be kept low.
Tested
Each batch is reported on a COA covering appearance, identification, assay, specific optical rotation, pH, loss on drying, calcium content and impurities such as 3-aminopropionic acid, so your QC team can release it quickly against the pharmacopoeia or feed specification you ordered.
Stored
Calcium pantothenate is hygroscopic and can cake or lose potency if it takes up moisture or is kept warm. Store bags and drums tightly closed in a cool, dry place away from strong oxidising agents, strong acids and bases, and follow the SDS.
Glossary
Terms you will meet on quotations, specifications and documents for Calcium Pantothenate.
FAQ
Anything else, call +91 98191 11179 or write to source@chelorapharmachem.com.
Request a QuoteCalcium pantothenate (CAS 137-08-6) is the vitamin B5 used in B-complex and multivitamin tablets, capsules and syrups, in fortified cereals, infant formula and health drinks, and in vitamin premixes for pigs, poultry and other livestock. Smaller amounts go into shampoos, hair tonics and cell-culture media.
The CAS number of calcium D-pantothenate is 137-08-6 and the EC number is 205-278-9. Its formula is C18H32CaN2O10 and its molar mass is 476.53 g/mol. Racemic DL-calcium pantothenate has a different CAS number, 6381-63-1, so quote the CAS number on your enquiry.
Calcium pantothenate is the calcium salt of vitamin B5 (D-pantothenic acid). The free acid is an unstable oil, so the vitamin is almost always supplied, weighed and labelled as calcium D-pantothenate. About 92% of its weight is pantothenic acid.
Calcium D-pantothenate (CAS 137-08-6) contains only the biologically active D-isomer and is dextrorotatory. DL-calcium pantothenate (CAS 6381-63-1) is a racemic mixture with about half the vitamin activity and an optical rotation close to zero. Pharma and food grades are normally the D-form; check the label and rotation on the COA.
No. Panthenol (pantothenol) is the alcohol analogue of pantothenic acid, usually supplied as a viscous liquid, and is widely used in cosmetics. Calcium pantothenate is a solid calcium salt of the acid. Both provide vitamin B5 activity, but they are different substances with different CAS numbers and are not interchangeable in a formula.
We supply pharmacopoeia grades to IP, BP, USP and EP, FCC food grade and 98% feed grade, in powder or granular form, subject to availability. Tell us the grade, the application and any particle-size requirement when you enquire.
Keep it in tightly closed containers in a cool, dry and well-ventilated store, protected from moisture and heat and away from strong oxidising agents, acids and bases. It is hygroscopic, so reseal part-used packs promptly. Follow the storage section of the SDS supplied with the batch.
Calcium pantothenate is generally classified under HS subheading 2936.24, D- or DL-pantothenic acid (vitamin B5) and its derivatives. In the Indian tariff it falls under 2936 24 00. Confirm the full code with your customs broker before import or export.
It has low hazard. Most producer SDS list it as not classified, though some supplier SDS mention possible skin, eye or respiratory irritation, and fine dust can form explosive mixtures with air. Read the SDS before handling, and use eye protection, gloves and dust control.
Calcium pantothenate is not regulated as a dangerous good for road, sea or air transport and has no UN number. Always check the transport section of the SDS supplied with the batch.
We provide a batch-wise Certificate of Analysis (COA), SDS/MSDS and specifications. Additional documents for vendor qualification can be arranged on request.
Yes. We handle requirements from samples and trial lots for R&D, formulation and vendor approval up to regular bulk supply for commercial production, subject to product availability.
We supply buyers across India, including Maharashtra, Gujarat, Telangana, Andhra Pradesh, Himachal Pradesh, Goa, Karnataka, Tamil Nadu, Madhya Pradesh, Uttarakhand and Sikkim, from our centralized sales office in Mumbai.
Email source@chelorapharmachem.com or source@cheloragroup.com, call +91 98191 11179, or use the enquiry form on this page. Include the quantity, grade, delivery location and target date.
Request a Quote
Tell us the quantity, grade and delivery location. Our centralized sales team replies with competitive pricing, lead time and documentation.
